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YKui 给想先看清步骤的家庭。本站介绍健康评估、就医、宠物健康、教育、财务和移民：每条能做什么、不能做什么。这里不提交病历、账户或申请材料。会员区登录尚未开放，目前请发邮件至 [email protected]。 YKui is for families who want the steps first. This site introduces health assessment, medical care, pet health, education, money, and immigration: what each line can and cannot do. Do not send medical records, account papers, or application files here. Sign-in to the members area is not open yet. For now, email [email protected].
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服务线·Service lines

健康评估、就医、宠物、教育、财务和移民都在这里。每条只说明步骤和边界。标了即将推出的，现在还不能用。会员区登录尚未开放，目前请先发邮件。 Health assessment, medical care, pets, education, money, and immigration are here. Each line explains the steps and the limits. Cards marked coming soon, or not written yet, cannot be used now. Sign-in to the members area is not open yet. For now, please email us.
更多服务 · More services

会员区 · Members

登录后在这里处理敏感材料（档案、个案、文件）。本站目前还不能真正登录。 After you sign in, sensitive materials (records, cases, and files) are handled here. This site does not have a working sign-in yet.

了解会员区 · About the members area →

TIME 长寿领袖 2026 TIME Longevity Leaders 2026

展示顺序非 TIME 排名 / Display order is not a TIME ranking

《时代》周刊首次发布这一名单，刊于 2026年8月20日，共 12 人，所列不分先后。 TIME's first list of this kind, published August 20, 2026. Twelve people, in no particular order.

来源：TIME（2026-08-20）/ Source: TIME (Aug 20, 2026)

  • 入选 / Honoree
    山中伸弥，Shinya Yamanaka

    山中伸弥Shinya Yamanaka

    京都大学 iPS 细胞研究与应用中心（CiRA）教授兼名誉所长，同时在 Gladstone Institutes 有实验室；2012 年诺贝尔生理学或医学奖得主。Professor and director emeritus, Center for iPS Cell Research and Application (CiRA), Kyoto University, with a laboratory at the Gladstone Institutes; 2012 Nobel Prize in Physiology or Medicine.

    部分重编程可能让人活得更健康、更长；但首要目标是延长健康寿命，而不只是寿命。Partial reprogramming may help people live healthier and longer, but the priority is healthspan, not lifespan alone.

    更多 / More

    Photo: Dɐ / Wikimedia Commons (CC0)

    TIME 引语“Our first priority is to extend healthy longevity, not just longevity itself.”

    TIME 原文 / Read on TIME

  • 入选 / Honoree
    David Sinclair

    辛克莱David Sinclair

    哈佛医学院遗传学家；LifeBiosciences 联合创始人。Geneticist at Harvard Medical School; co-founder of LifeBiosciences.

    “衰老信息论”：用三个山中因子恢复细胞丢失的表观遗传信息；首个青光眼和非动脉炎性前部缺血性视神经病（NAION）试验已于 2026 年 6 月开始给药。“Information theory of aging”: restoring lost epigenetic information with three Yamanaka factors; first glaucoma and non-arteritic anterior ischemic optic neuropathy (NAION) trial dosed June 2026.

    更多 / More

    Photo: Editor5627 / Wikimedia Commons, CC BY-SA 4.0

    TIME 引语“What we are doing is erasing the noise and re-establishing the original signal.”

    TIME 原文中的争议Criticism noted by TIME TIME 指出，他因大胆的说法，以及一连串尚未产出持久成果的公司而受到批评；试验结果尚未公布。TIME notes he has been criticised for bold claims and a string of companies that have not yet produced lasting results. Trial results have not yet been published.

    利益冲突提示：公司联合创始人。 / Conflict of interest: company co-founder.

    TIME 原文 / Read on TIME

  • 入选 / Honoree

    Nir Barzilai

    领导 Albert Einstein 医学院老年科学研究所；Academy of Geroscience 主席。Leads the Institute of Geroscience at Albert Einstein College of Medicine; president of the Academy of Geroscience.

    靶向衰老生物学来延长健康寿命，推动老药新用；他设计的二甲双胍 TAME 试验尚未启动。Targeting the biology of aging to extend healthspan, and finding new uses for existing drugs. The metformin TAME trial he designed has not started.

    更多 / More

    TIME 引语“Longevity is the outcome. Geroscience is the mechanism.”

    TIME 原文 / Read on TIME

  • 入选 / Honoree

    Gabrielle Lyon

    执业医生；2018 年创办远程医疗诊所 Strong Medical；Forever Strong Center 联合创始人。Practicing physician; founded the telehealth clinic Strong Medical in 2018; co-founder of Forever Strong Center.

    肌肉是“长寿的器官”，属于预防医学。Muscle is “the organ of longevity,” and it belongs to preventive medicine.

    更多 / More

    利益冲突提示：有诊所、书籍和播客等商业利益。 / Conflict of interest: commercial interests include a clinic, books, and a podcast.

    TIME 原文 / Read on TIME

  • 入选 / Honoree

    Myechia Minter-Jordan

    AARP 首席执行官（2024 年 11 月起），医生出身。CEO of AARP since November 2024; a physician by training.

    衰老是“所有人”的议题；要缩小健康寿命与寿命之间约 12.5 年的差距（这是她本人的说法）。Aging is an issue for “everyone.” She says the gap between healthspan and lifespan, about 12.5 years, should be narrowed.

    更多 / More

    TIME 引语“This is a longevity revolution.”

    TIME 原文 / Read on TIME

  • 入选 / Honoree

    Tony Wyss-Coray

    斯坦福大学神经学教授，Knight Initiative for Brain Resilience 主任；Vero Bioscience 与 Alkahest 联合创始人。Professor of neurology at Stanford University and director of the Knight Initiative for Brain Resilience; co-founder of Vero Bioscience and Alkahest.

    用血液蛋白测量“器官级生物年龄”；器官越“老”，疾病风险越高。Blood proteins can measure “organ-level biological age”; the “older” an organ, the higher the disease risk.

    更多 / More

    利益冲突提示：公司联合创始人。 / Conflict of interest: company co-founder.

    TIME 原文 / Read on TIME

  • 入选 / Honoree

    Jamie Justice

    XPRIZE Healthspan 执行主任，老年学研究者。Executive director of XPRIZE Healthspan; a researcher in gerontology.

    长寿领域需要统一的证据“过滤器”，所有参赛者用同一标准检验。The longevity field needs a shared evidence “filter,” with every entrant tested by the same standard.

    更多 / More

    TIME 引语“There's no shortage of brilliant science and quackery.”

    TIME 原文 / Read on TIME

  • 入选 / Honoree
    Juan Carlos Izpisua Belmonte

    Juan Carlos Izpisua Belmonte

    Salk 研究所长期教授；Altos Labs 联合创始人。Longtime professor at the Salk Institute; co-founder of Altos Labs.

    衰老源于细胞“身份”丧失，部分重编程或可恢复；他本人也提醒，小鼠不是人。Aging comes from a loss of cellular “identity,” which partial reprogramming might restore. He also cautions that “a mouse is not a human.”

    更多 / More

    Photo: Chris Keeney / Salk Institute for Biological Studies, CC BY-SA 4.0

    TIME 引语“I feel disease and aging have to do with cell identity.”

    利益冲突提示：公司联合创始人。 / Conflict of interest: company co-founder.

    TIME 原文 / Read on TIME

  • 入选 / Honoree

    Robert Waldinger

    精神科医生；哈佛成人发展研究主任（2003 年起）。Psychiatrist; director of the Harvard Study of Adult Development since 2003.

    社会联结影响衰老和健康；孤立的人更早患上衰老相关疾病。Social connection affects aging and health; people who are isolated develop aging-related diseases earlier.

    更多 / More

    TIME 引语“Invest in other people.”

    TIME 原文 / Read on TIME

  • 入选 / Honoree
    Andrea Maier

    Andrea Maier

    新加坡国立大学 Academy for Healthy Longevity 主任。Director of the Academy for Healthy Longevity at the National University of Singapore.

    要解决长寿医学的“证据问题”，做按生物年龄分层的精准临床试验。Addressing longevity medicine's “evidence problem,” with precise clinical trials stratified by biological age.

    更多 / More

    Photo: Universiteit van Nederland (YouTube), via Wikimedia Commons, CC BY 3.0

    TIME 引语“Aging is so heterogeneous.”

    TIME 原文 / Read on TIME

  • 入选 / Honoree
    Uri Alon

    Uri Alon

    魏茨曼科学研究所 Sagol 长寿研究所所长，系统生物学家。Head of the Sagol Institute for Longevity Research at the Weizmann Institute of Science; a systems biologist.

    排除外因死亡后，人与人之间寿命差异的约一半可归因于遗传（2026 年 1 月的研究）；生活方式仍然重要。After deaths from external causes are set aside, about half of the variation in lifespan between people is attributable to genes, according to a January 2026 study; lifestyle still matters.

    更多 / More

    Photo: Weizmann Institute of Science, public domain

    TIME 引语“After the study, I still swim and eat salads for lunch.”

    TIME 原文 / Read on TIME

  • 入选 / Honoree

    Francesca Duncan

    西北大学兼 Buck 衰老研究所生殖生物学家。Reproductive biologist at Northwestern University and the Buck Institute for Research on Aging.

    卵巢是女性健康长寿的核心器官。The ovary is a central organ for women's healthy longevity.

    更多 / More

    TIME 引语“…you absolutely cannot have a conversation about health span unless you're also talking about the ovaries…”

    TIME 原文 / Read on TIME

左右滑动查看 / Swipe to see more

长寿医学前沿周报 Longevity Medicine Weekly

每周一期。 One issue a week.

长寿医学前沿周报 · 第 1 期Longevity Medicine Frontier Weekly · Issue 1 2026年9月28日-10月4日 / 28 Sep-4 Oct 2026

第 1 期收录近期发表的 4 篇论文（发表于 2026年8月29日-10月2日），按证据等级排列。只介绍研究发现，不构成医疗建议；任何健康或用药决定，请先咨询您的医生。 Issue 1 covers 4 recent papers (published 29 Aug-2 Oct 2026), listed by strength of evidence. It summarizes research only and is not medical advice. Please talk to your doctor before making any health or medication decision.

  • 近万名 70 岁以上老人的他汀随机试验：心血管事件减少，无失能生存未见改善 Statin trial in nearly 10,000 adults aged 70+: fewer cardiovascular events, no gain in disability-free survival

    在澳大利亚社区招募的 70 岁以上、没有心血管病、糖尿病或痴呆的老人中，阿托伐他汀组在中位 5.9 年里主要心血管事件的风险比安慰剂组低约 30%，但"未死亡、未患痴呆、没有持续失能"的比例没有明显差别，肌肉、肝胆和糖尿病相关的不良事件在用药组更常见；参与者以白人为主，结果未必适用于更衰弱或同时患多种疾病的老人。 Among community-dwelling Australians aged 70 or older without heart disease, diabetes, or dementia, those given atorvastatin had about a 30% lower risk of major cardiovascular events than those on placebo over a median of 5.9 years, but survival free of dementia and lasting disability did not clearly differ, and muscle, liver, and diabetes-related side effects were more common with the drug; most participants were White, so the results may not apply to frailer older adults or those with several conditions.

    证据类型Evidence 人体 RCT 或荟萃分析 · Human RCT or meta-analysis

    期刊Journal The New England Journal of Medicine

    发表Published

    原文Original

  • 苏格兰老年队列：哪些衰老指标与 16 年死亡风险关系更密切 A Scottish ageing cohort: which ageing measures track most closely with 16-year mortality

    研究对约 860 名七十多岁的苏格兰老人随访 16 年，发现表观遗传年龄更大、脑容量更小、肺功能更差和认知更差，与死亡风险的关联比近年兴起的血浆蛋白"器官时钟"更强，并筛出 368 个与死亡风险相关的血浆蛋白；这是关联研究，不能说明因果，参与者也较健康、族群单一，结论需要在其他人群中验证。 Following about 860 Scottish adults in their 70s for 16 years, the study found that older epigenetic age, smaller brain volume, weaker lung function, and poorer cognition were more strongly linked to death than newer blood-protein "organ clocks", and it identified 368 blood proteins linked to mortality risk; this shows association, not cause, and the group was relatively healthy and ethnically homogeneous, so the findings need checking in other populations.

    证据类型Evidence 队列研究 · Cohort study

    期刊Journal Aging Cell

    发表Published

    原文Original

    利益冲突Conflict of interest 两位作者披露了与企业的关系：一位担任 Epigenetic Clock Development Foundation 和 Optima Partners 的顾问；另一位是 Centia Bio 联合创始人，并曾为本研究所用蛋白检测平台的厂商 SomaLogic 做过无偿报告。论文写明研究独立于 Centia Bio 开展，经费来自公共和慈善机构。 Two authors disclosed ties to companies: one advises the Epigenetic Clock Development Foundation and Optima Partners; another co-founded Centia Bio and has given unpaid talks for SomaLogic, maker of the protein test platform used in this study. The paper states the work was done independently of Centia Bio and was funded by public and charitable bodies.

  • 小鼠研究：阻断 PD-L2 或可帮助免疫系统清除衰老细胞 Mouse study: blocking PD-L2 may help the immune system clear senescent cells

    研究发现衰老细胞上的 PD-L2 蛋白会随年龄增多，可能帮助这些细胞躲过免疫清除；缺少 PD-L2 的老年小鼠体内衰老细胞更少、胰岛素敏感性和握力更好，抗 PD-L2 处理也改善了老年小鼠的胰岛素敏感性；人体细胞和血液样本只提供了相关线索，目前没有人体获益的证据。 Senescent cells carry more of a protein called PD-L2 as we age, which may help them hide from immune clearance; old mice lacking PD-L2 had fewer senescent cells and better insulin sensitivity and grip strength, and anti-PD-L2 treatment improved insulin sensitivity in old mice; human cell and blood samples offer only supporting clues, and there is no evidence yet of benefit in people.

    动物研究·结论未必适用于人 Animal study, may not apply to humans

    证据类型Evidence 动物研究 · Animal study

    期刊Journal Cell Metabolism

    发表Published

    原文Original

    利益冲突Conflict of interest 多位作者持有与 PD-L2 或清除衰老细胞药物相关的专利或在审专利，其中部分 PD-L2 专利已授权给一家衰老细胞疗法公司；一位作者持有多家长寿领域生物技术公司的股份。 Several authors hold patents or pending patents related to PD-L2 or to drugs that clear senescent cells, and some PD-L2 patents have been licensed to a senescence-therapy company; one author holds shares in several longevity biotech companies.

  • 观点："生物学年龄"下降，等于衰老被逆转了吗？ Perspective: does a lower "biological age" mean ageing has been reversed?

    多位衰老研究者撰文区分"衰老"和"生物学年龄"这两个概念，讨论"年龄逆转"一类说法到底指什么、需要拿出怎样的证据，以及讨论这一问题时的用词；这是观点文章，没有提供新的研究数据。 A group of ageing researchers separates "ageing" from "biological age", asking what "age reversal" claims actually mean, what burden of proof they carry, and how the words used in this debate matter; this is a perspective piece and presents no new study data.

    证据类型Evidence 观点 · Opinion/Perspective

    期刊Journal Cell Metabolism

    发表Published

    原文Original

    利益冲突Conflict of interest 论文声明作者无利益冲突；其中一位作者的署名单位是长寿领域公司 Optispan。 The authors declare no competing interests; one author lists the longevity company Optispan as an affiliation.

内容仅供信息参考，不构成医疗建议 / For information only, not medical advice

创始人寄语·Founder’s Note

YKui 由一位海归医学/科学双博士创立。我们致力于将前沿超级智能（SI）与生命长寿领域的突破性成果相融合，为人类与伴侣动物的长寿与健康提供可持续的智能服务。 YKui was founded by a returnee MD-PhD, with doctorates in both medicine and science. We unite frontier Super Intelligence (SI) with breakthroughs in longevity science to deliver durable, intelligent services for the longevity and health of people and companion animals.

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